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Superoxide combines with NO to form peroxynitrite that oxidizes BH 4 and destabilizes eNOS to produce more superoxide 22, 24, 25 thus, further enhancing the development of oxidative stress

In addition, Ref(2)P is the Drosophila homologue of mammalian P62, which functions as a substrate of autophagy to deliver ubiquitinated protein into autophagosome [21]

Importantly, lactulose treatment improved low-grade cerebral edema in patients with CHE [58]

Conclusions The combined effects of exercise and polyphenol supplementation offer a promising, non-pharmacological approach for managing depression and enhancing brain function

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